Eric William Endsley

Title: Innovations by Eric William Endsley

Introduction

Eric William Endsley is a notable inventor based in Ann Arbor, Michigan. He has made significant contributions to the field of live cell visualization and analysis, holding a total of six patents. His work focuses on developing systems and methods that enhance the imaging and analysis of cell samples in incubators.

Latest Patents

One of his latest patents involves systems and methods for automatically imaging and analyzing cell samples in an incubator. An actuated microscope is utilized to generate images of samples within wells of a sample container over extended periods, such as days, weeks, or months. A plurality of images is produced for each scan of a specific well, and these images are employed to analyze metabolically active cells. The analysis includes generating a 'range image' by subtracting the minimum intensity value across the scan for each pixel from the maximum intensity value. This range image emphasizes cells or portions of cells that exhibit changes in activity over the scan period, such as neurons, myocytes, and cardiomyocytes, while de-emphasizing regions with consistently high intensities unrelated to cell activity.

Career Highlights

Eric has worked with prominent companies in the field, including Essen Instruments, Inc. and Sartorius Bioanalytical Instruments, Inc. His experience in these organizations has contributed to his expertise in live cell imaging technologies.

Collaborations

Throughout his career, Eric has collaborated with notable colleagues, including Kirk S. Schroeder and Daniel Appledorn. These collaborations have further enriched his work and innovations in the field.

Conclusion

Eric William Endsley is a distinguished inventor whose work in live cell visualization and analysis has made a significant impact in the scientific community. His innovative patents and collaborations reflect his dedication to advancing technology in this important area.