This inventor holds 2 USPTO granted patents and 2 published patent applications. Top assignees: Massachusetts Institute of Technology, Albert Einstein College of Medicine. Active years: 1999-2003.
Company Filing History:
2 out of 8,573 
1 out of 513 
Years Active: 1999-2003
Title: Eric Bouhassira: Innovator in Cell Transformation Technologies
Introduction
Eric Bouhassira is a notable inventor based in Hastings on Hudson, NY (US). He has made significant contributions to the field of cell transformation, holding a total of 2 patents. His work focuses on methods and compositions that enable efficient and stable site-specific integration of transgenes.
Latest Patents
Bouhassira's latest patents include innovative methods for transforming cells. These methods disclose techniques for achieving efficient and stable site-specific integration of transgenes. Transformation is accomplished by providing an acceptor DNA containing two inverted lox sequences and a donor DNA with the same sequences. The process involves contacting the acceptor and donor DNA with a recombinase, such as Cre or Flp, which facilitates recombination at the lox sequences. Prior to this recombination, the acceptor DNA is typically integrated into the genome of a cell, such as an embryonic stem cell or a fertilized egg. Additionally, the acceptor DNA may include a negatively selectable marker to screen for cells that have undergone the desired site-specific recombination.
Another patent focuses on introducing an acceptor vector, preferably a retroviral vector, into a cell. This vector integrates into the cell's genome and comprises two incompatible lox sequences, L1 and L2. A donor vector containing a transgene flanked by the same L1 and L2 sequences is then introduced. Stable gene transfer is initiated by contacting the lox L1 and L2 sequences with Cre recombinase.
Career Highlights
Throughout his career, Bouhassira has worked with prestigious institutions, including the Massachusetts Institute of Technology and Albert Einstein College of Medicine. His research has significantly advanced the understanding and application of gene transformation techniques.
Collaborations
Some of his notable coworkers include Philippe LeBoulch and Karen Westerman. Their collaborative efforts have contributed to the development of innovative solutions in the field of cell transformation.
Conclusion
Eric Bouhassira's work in cell transformation technologies showcases his innovative spirit and dedication to advancing scientific knowledge. His patents reflect a commitment to improving methods for gene integration, which could have far-reaching implications in biotechnology and medicine.