Eon Soo Lee

Title: Innovations of Eon Soo Lee in Micro Biochip Technology

Introduction

Eon Soo Lee is a prominent inventor based in Tenafly, NJ (US), known for his significant contributions to the field of micro biochip technology. With a total of 11 patents, Lee has developed innovative solutions that enhance disease diagnosis through advanced detection methods.

Latest Patents

One of his latest patents is the "Enhanced sensitivity and specificity for point-of-care (POC) micro biochip." This invention includes an apparatus and method to detect disease-specific antigens, which assists in disease diagnosis. The POC micro biochip incorporates at least one hydrophilic microchannel for controlled and self-driven flow of body fluid. Metallic nano-interdigitated electrodes are disposed within the channels to provide enhanced sensitivity detection. The microchannel controls flow and amplifies a capillary effect, while electrodes are fabricated on the microchannel surface to detect biomolecular interactions. When a sample flows through the microchannel, disease-specific antigens from the sample form an antigen-antibody complex with antibodies immobilized on the electrodes. The antigen-antibody interaction is detected via an electrical change in the biochip's nano circuit. Each electrode may include a different antibody to detect various antigens. Notably, capacitance during antigen-antibody interaction without microfluidic flow is higher than with microfluidic flow due to the instability of immobilized antibodies on the sensing surface caused by shear stress. This POC biochip provides nano-level detection of many disease-specific antigens based on micro volume or single drop-sized samples.

Another significant patent is the "Microfluidic biochip with enhanced sensitivity." This microfluidic biochip is designed for detecting disease antigens using a gold nano interdigitated electrode circuit under controlled self-driven flow conditions. The biochip incorporates hydrophilic microchannels for controlled self-driven flow and gold nano interdigitated electrodes for capacitive sensing with enhanced sensitivity. The microchannel's surface is treated with oxygen plasma to control hydrophilicity and flow rate of the biofluid sample. Carbon Nanotubes (CNTs) are utilized as an intermediate layer to enhance the binding capability to nano electrodes, further improving sensitivity. The carboxylic groups of the CNTs allow for covalent bond binding between the antibodies and the CNTs, facilitating better adherence of antibodies on the electrode surfaces. The high surface area ratio of CNTs increases the quantity of