Location History:
- Houston, TX (US) (2012)
- Sodra Sanby, SE (2021)
Company Filing History:
Years Active: 2012-2021
Title: Emanuel Smeds: Innovator in Microbial Surface Components
Introduction
Emanuel Smeds is a notable inventor based in Sodra Sanby, Sweden. He has made significant contributions to the field of microbial surface components, particularly in the development of vaccines and therapeutic agents. With a total of 2 patents, his work is recognized for its potential impact on medical science.
Latest Patents
Smeds' latest patents include the "Crystal structure of clumping factor A in complex with fibrinogen derived peptide and uses thereof." This invention discloses the crystal structure of Clumping factor A (ClfA) in complex with a fibrinogen (Fg) derived peptide. The patent outlines the use of this structure in designing ClfA-targeted vaccines and therapeutic agents, including monoclonal antibodies. Additionally, it presents an isolated and purified engineered ClfA protein with a stabilized, closed conformation, along with immunogenic compositions and methods for treating infections in individuals.
Another significant patent focuses on a method for determining the structure of microbial surface components recognizing adhesive matrix molecules in complex with fibrinogen. This involves providing a ClfA complexed with a fibrinogen gamma-peptide and identifying critical amino acid residues that facilitate the ClfA:fibrinogen gamma-peptide interaction. The patent aims to model the structure of the ClfA binding region and identify potential agents that inhibit this interaction without affecting other protein bindings.
Career Highlights
Emanuel Smeds is affiliated with the Texas A&M University System, where he continues to advance his research in microbial components. His work has garnered attention for its innovative approach to addressing complex medical challenges.
Collaborations
Smeds collaborates with esteemed colleagues, including Magnus A Hook and Ya-Ping Ko, who contribute to his research endeavors. Their combined expertise enhances the potential impact of their work in the scientific community.
Conclusion
Emanuel Smeds is a pioneering inventor whose contributions to the field of microbial surface components are shaping the future of medical science. His innovative patents and collaborations highlight his commitment to advancing healthcare solutions.