Location History:
- Burlingame, CA (US) (1985 - 1992)
- Palo Alto, CA (US) (1992)
Company Filing History:
5 out of 7,865 
1 out of 22 
1 out of 1 Years Active: 1985-1992
Title: Emanuel Calenoff: Innovator in DNA Assay Technology
Introduction
Emanuel Calenoff is an accomplished inventor based in Burlingame, California. With a remarkable portfolio of nine patents, Calenoff has made significant contributions to the field of biotechnology, particularly in the development of assays for detecting specific DNA sequences.
Latest Patents
Two of his latest innovations include the "DNA Probe Diffraction Assay and Reagents" and the "Fluorometric Assay of Chymopapain Hypersensitivity and Reagents Therefor". The DNA probe diffraction assay utilizes DNA sequences as probes in a nucleic acid hybridization diffraction assay to detect specific DNA sequences. This invention addresses non-specific hybridization by introducing advanced supporting surfaces for a biogrid or biograting. Employing a preferred method, it involves creating a biograting for use in light diffraction assays, where a nucleotide sequence hybridizing reagent is adhered to a smooth, solid surface, followed by exposure to UV radiation. This process crafts a biological diffraction grating that enhances assay accuracy.
In his second recent patent, the fluorometric assay targets chymopapain-specific IgE antibody levels in patient serum. The method allows for the binding of chymopapain-specific IgE to an insoluble support and its subsequent quantification through a labeled anti-IgE antibody. This innovation is crucial for advancing our understanding of hypersensitivity related to chymopapain.
Career Highlights
Throughout his career, Emanuel Calenoff has been associated with prominent companies such as Minnesota Mining and Manufacturing Company (3M) and Adeza Biomedical Corporation. His work in these organizations has enabled him to drive forward important biotechnological advancements and foster innovations.
Collaborations
Calenoff has collaborated with notable professionals in the field of biotechnology, including Yuh-Geng Tsay and Ruth M. Jones. Their collective efforts have contributed to the successful development of new diagnostic assays, improving methodologies within the industry.
Conclusion
Emanuel Calenoff stands out as a pivotal figure in the realm of DNA assay technology. His inventions are not only groundbreaking but also play a crucial role in advancing diagnostic capabilities, offering new insights for medical and research fields alike. As he continues to innovate, his work promises to leave an indelible mark on biotechnology.