Company Filing History:
Years Active: 2014-2016
Title: Eliud Hernandez: Innovator in Cancer Research
Introduction
Eliud Hernandez is a prominent inventor based in San Juan, Puerto Rico. He has made significant contributions to the field of cancer research, particularly in the development of small-molecule inhibitors targeting Rac1 in metastatic cancer cells. His innovative work has the potential to advance therapeutic strategies for cancer treatment.
Latest Patents
Eliud Hernandez holds two patents related to small-molecule inhibitors of Rac1. His latest patents include a novel inhibitor of Rac activity based on the structure of the established Rac/Rac-GEF inhibitor NSC23766. The compound EHop-016, with an IC50 of 1.1 μM, is a 100-fold more efficient inhibitor of Rac activity than NSC23766. EHop-016 is specific for Rac1 and Rac3 at concentrations ≤5 mM. At higher concentrations, EHop-016 inhibits the close homolog Cdc42. In MDA-MB-435 cells, EHop-016 (≤5 mM) inhibits the association of the Rac-GEF Vav2 with a nucleotide-free Rac1(G15A), which has a high affinity for activated GEFs. EHop-016 does not affect the association of the Rac-GEF Tiam-1 with Rac1(G15A) at similar concentrations. Additionally, EHop-016 inhibits the Rac activity of MDA-MB-231 metastatic breast cancer cells and reduces Rac-directed lamellipodia formation in both cell lines. EHop-016 decreases Rac-downstream effects of p21-activated kinase (PAK)1 activity and directed migration of metastatic cancer cells. At low concentrations (<5 μM), EHop-016 does not affect cell viability.
Career Highlights
Eliud Hernandez is affiliated with the University of Puerto Rico, where he conducts his research and development work. His innovative contributions to cancer research have positioned him as a key figure in the scientific community.
Collaborations
Eliud has collaborated with notable colleagues, including Cornelis P Vlaar and Suranganie Dharmawardhane, to further advance his research initiatives.
Conclusion
Eliud Hernandez is a dedicated inventor whose work in developing small-molecule inhibitors has the potential to significantly impact cancer treatment. His innovative research continues to pave the way for new therapeutic strategies in the fight against
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