Elio F Vanin

Title: Elio F Vanin: Innovator in Gene Therapy

Introduction

Elio F Vanin is a notable inventor based in Memphis, TN (US), recognized for his contributions to the field of gene therapy. With a total of 3 patents, Vanin has made significant strides in the development of methods for gene transfer into human stem cells.

Latest Patents

One of his latest patents is titled "Highly efficient gene transfer into human repopulating stem cells by RD114 pseudotyped retroviral vector particles." This invention pertains to a method for efficiently introducing exogenous genes into stem cells, particularly human stem cells. The method includes steps for inducing the proliferation of target cells by pre-stimulation with cytokines and/or growth factors, followed by incubating these cells with RD114-pseudotyped vector particles. The invention also discloses a method for somatic gene therapy, which can be used for various therapeutic applications. It involves introducing a gene of interest contained within the retroviral genome into human repopulating stem cells, followed by introducing these cells into a human host. Additionally, the invention provides a method for monitoring the efficiency of the stem cell-mediated gene transfer based on detecting the presence of the genes or their expression products in various stem cell-derived lineages of the host.

Another significant patent is related to "Stable virus packaging cell lines." This invention focuses on recombinant packaging and producer cell lines for producing infectious retroviral vectors. It specifically relates to the generation of pseudotyped retroviral vectors with a broad host range, which can be produced at high titers in specially constructed packaging cell lines. The invention emphasizes the generation of pseudotyped retroviral vectors having vesicular stomatitis virus-G protein (VSV-G) as the membrane-associated viral envelope protein.

Career Highlights

Throughout his career, Elio F Vanin has worked with esteemed organizations such as St. Jude Children's Research Hospital and Genetic Therapy, Inc. His work has significantly impacted the field of gene therapy and has contributed to advancements in medical research.

Collaborations

Vanin has collaborated with notable individuals in the field, including Arthur W Nienhuis and Patrick F Kelly. These collaborations have further enhanced his research and innovations in gene therapy.

Conclusion

Elio F Vanin is a prominent inventor whose work in gene therapy has paved the way for new therapeutic applications. His