Company Filing History:
Years Active: 1988-2002
Title: **Eleanor A. Miele: Innovator in RNA Research**
Introduction
Eleanor A. Miele, based in Brooklyn, NY, is a prominent inventor with a significant contribution to the field of recombinant RNA technology. With a total of five patents to her name, Miele's work paves the way for advancements in molecular biology and genetic engineering.
Latest Patents
Miele's latest patents showcase her innovative approach in developing tools for RNA research. One of her notable inventions is a **replicatable hybridizable recombinant RNA probe**. This invention provides researchers with a means to create single-stranded RNA probe molecules, complete with recognition sequences for RNA-directed RNA polymerases. It includes a heterologous RNA sequence that allows for the determination of the presence and concentration of specific oligonucleotides in various samples.
Another landmark patent involves **autocatalytic replication of recombinant RNA**. This method allows for the production of mutant viruses or viroids by utilizing recombinant single-stranded RNA molecules. The technology enables researchers to incubate RNA under selective conditions, facilitating the selection of mutant populations essential for various applications in virology and RNA biology.
Career Highlights
Eleanor A. Miele works at Columbia University, where she has contributed significantly to research and innovation in their scientific community. Her expertise in RNA technology not only enhances the university’s research capabilities but also pushes the boundaries of what can be achieved in molecular diagnostics and therapeutics.
Collaborations
Throughout her career, Miele has collaborated with esteemed colleagues including Fred Russell Kramer and Donald R. Mills. These partnerships reflect her commitment to advancing scientific knowledge and her ability to work effectively in team-based environments, often leading to groundbreaking discoveries.
Conclusion
Eleanor A. Miele’s contributions to RNA research demonstrate her status as a leading inventor in her field. With her five patents, she continues to influence molecular biology, paving the way for future innovations that could greatly impact research and medical applications. Her work at Columbia University and collaboration with esteemed peers further underscores the importance of collaborative efforts in scientific advancements.