Elad B Gil

Title: Elad B Gil: Innovator in Hormone Receptor Functional Dimers

Introduction

Elad B Gil is a prominent inventor based in Boston, MA, known for his significant contributions to the field of biochemistry and molecular biology. His innovative work focuses on the development of chimeric proteins that have the potential to revolutionize gene expression modulation.

Latest Patents

Elad B Gil holds a patent titled "Hormone receptor functional dimers and methods of their use." This invention provides chimeric proteins that consist of at least two functional protein units, each containing the dimerization domain of a member of the steroid/thyroid hormone nuclear receptor superfamily. The chimeric proteins are designed to fold under crystallization conditions to form functional entities. These entities may include a novel flexible peptide linker of variable lengths, which aids in the preparation of variant chimeric proteins. The DNA binding characteristics of these functional entities differ from those of wild-type complexes formed between 'monomeric' receptors and their binding partners. Some functional entities, such as dimers expressed as fusion proteins, can transactivate responsive promoters similarly to wild-type complexes, while others function as constitutive repressors. The invention also encompasses nucleotide sequences encoding the chimeric proteins, cells containing these sequences, and methods for using the proteins to modulate gene expression in a subject organism. Additionally, isolated protein crystals suitable for x-ray diffraction analysis and methods for obtaining potential ligands for the chimeric proteins are provided.

Career Highlights

Elad B Gil is affiliated with the Salk Institute for Biological Studies, where he continues to advance his research in the field of hormone receptors and protein engineering. His work has garnered attention for its potential applications in therapeutic interventions and genetic research.

Collaborations

Elad has collaborated with notable scientists such as Fred Harrison Gage and Steven T Suhr, contributing to a rich environment of innovation and discovery in his field.

Conclusion

Elad B Gil's contributions to the development of hormone receptor functional dimers exemplify the intersection of innovation and scientific research. His work not only enhances our understanding of protein interactions but also opens new avenues for gene expression modulation.