Company Filing History:
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Title: Efrat Shema-Yaacoby: Innovator in Chromatin Analysis
Introduction
Efrat Shema-Yaacoby is a prominent inventor based in Brookline, MA (US). She has made significant contributions to the field of chromatin biology through her innovative research and patented technologies. Her work focuses on understanding the complexities of protein modifications and their implications in epigenetic regulation.
Latest Patents
Efrat holds a patent titled "Combinatorial single molecule analysis of chromatin." This invention provides a method for single-molecule profiling of combinatorial protein modifications, combined with single-molecule sequencing of protein/nucleic acid complexes. The technology utilizes high-throughput single-molecule imaging to decode combinatorial modifications on millions of individual nucleosomes from pluripotent stem cells and lineage-committed cells. The invention identifies bivalent nucleosomes with both repressive and activating marks, as well as other combinatorial modification states that vary with developmental potency. Furthermore, the application of genetic and chemical perturbations of chromatin enzymes demonstrates a preferential effect on nucleosomes harboring specific modification states. This novel single-molecule technology can address fundamental questions in chromatin biology and epigenetic regulation, leading to potential advancements in therapeutics and diagnostics.
Career Highlights
Efrat has worked with notable organizations, including The General Hospital Corporation and Seqll LLC. Her experience in these institutions has allowed her to collaborate with leading experts in the field and contribute to groundbreaking research.
Collaborations
Efrat has collaborated with esteemed colleagues such as Bradley Bernstein and Daniel Jones. These partnerships have further enriched her research and expanded the impact of her work in the scientific community.
Conclusion
Efrat Shema-Yaacoby is a trailblazer in the field of chromatin analysis, with her innovative patent paving the way for new discoveries in epigenetics. Her contributions are poised to influence future research and therapeutic strategies.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.