Edwin J Hamilton, Jr

Title: Edwin J Hamilton, Jr: Innovator in Growth Hormone Technology

Introduction

Edwin J Hamilton, Jr. is a notable inventor based in Terre Haute, Indiana, who has made significant contributions to the field of biotechnology, particularly in the realm of growth hormones. With two patents to his name, Hamilton’s groundbreaking work demonstrates his commitment to enhancing biopharmaceutical products.

Latest Patents

Hamilton's latest patents focus on the stabilization of growth hormones and the isolation of bioactive, monomeric growth hormone. The first patent addresses the stabilization of growth hormones by admixing them with various stabilizers, which decreases the formation of insolubles and preserves the soluble bioactivity of the growth hormone in aqueous environments. Among the examples of stabilizers are specific polyols, amino acids, polymers of amino acids with charged side groups at physiological pH, and choline salts.

His second patent presents a method for isolating biologically active monomeric growth hormone from microbially produced insoluble inclusion bodies. This process involves solubilizing and denaturing the growth hormone by extracting it from inclusion bodies using guanidine salt solutions such as guanidine hydrochloride. After denaturing, Hamilton's method allows for the renaturation of the hormone by replacing the guanidine solution with a denaturant-free buffer, followed by purification through ion-exchange chromatography.

Career Highlights

Edwin J Hamilton, Jr. works at International Minerals & Chemical Corporation. His innovative approaches in the field of growth hormones have cemented his status as a key contributor to biopharmaceutical research and development. His attention to detail and thorough understanding of biochemical interactions are evident in his patented processes.

Collaborations

Throughout his career, Hamilton has collaborated with fellow experts in the field, including Bruce D Burleigh and Ren-der Yang. These collaborations have likely enriched his research and provided broader perspectives in advancing growth hormone technologies.

Conclusion

In summary, Edwin J Hamilton, Jr. is a prominent inventor whose work on growth hormone stabilization and isolation showcases innovative solutions in biotechnology. His patents reflect a dedication to improving the efficacy of growth hormones, benefiting both the scientific community and end-users. Hamilton’s contributions underscore the importance of collaboration and innovation in advancing healthcare technologies.