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For the Inventor, By the Inventor

Mercer Island, WA, United States of America

Edward Sebastian Lein

This inventor holds 7 USPTO granted patents and 14 published patent applications. Top assignees: Allen Institute, Seattle Children's Hospital, The United States of America, as Represented by the Secretary, Department of Health and Human Services. Active years: 2024-2026.

IDiyas Innovation Intelligence. (2026). Inventor Profile: Edward Sebastian Lein. Retrieved from https://idiyas.com/inventor/edward-sebastian-lein

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

USPTO Granted Patents = 7 

% Patents Active = 100.0

Average Co-Inventor Count = 7.9

ph-index = 1


Company Filing History:

goldMedal6 out of 16 
 
Allen Institute
 patents
silverMedal1 out of 89 
 
Seattle Children's Hospital
 patents
bronzeMedal1 out of 3,696 
 
The United States of America, as Represented by the Secretary, Department of Health and Human Services
 patents
where one patent can have more than one assignee

Years Active: 2024-2026

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7 patents (USPTO):Explore Patents
1. 12703873 - ARTIFICIAL EXPRESSION CONSTRUCTS FOR SELECTIVELY MODULATING GENE EXPRESSION IN EXCITATORY CORTICAL NEURONS (2026-08-11),
2. 12702722 - ARTIFICIAL EXPRESSION CONSTRUCTS FOR SELECTIVELY MODULATING GENE EXPRESSION IN SELECTED NEURONAL CELL POPULATIONS (2026-08-11),
3. 12692515 - ARTIFICIAL EXPRESSION CONSTRUCTS FOR SELECTIVELY MODULATING GENE EXPRESSION IN INHIBITORY NEOCORTICAL NEURONS (2026-07-28),
4. 12674181 - ARTIFICIAL EXPRESSION CONSTRUCTS FOR MODULATING GENE EXPRESSION IN CHANDELIER CELLS (2026-07-07),
5. 12655444 - Artificial expression constructs for selectively modulating gene expression in non-neuronal brain cells (2026-06-16),
6. 12467064 - ARTIFICIAL EXPRESSION CONSTRUCTS FOR SELECTIVELY MODULATING GENE EXPRESSION IN INTERNEURONS (2025-11-11),
7. 12121563 - Rescuing voltage-gated sodium channel function in inhibitory neurons (2024-10-22),

Title: The Innovations of Edward Sebastian Lein

Introduction

Edward Sebastian Lein is an accomplished inventor based in Mercer Island, WA (US). He has made significant contributions to the field of neuroscience, particularly in the area of voltage-gated sodium channels. His work has the potential to impact the treatment of various neurological disorders.

Latest Patents

Lein holds a patent titled "Rescuing voltage-gated sodium channel function in inhibitory neurons." This patent describes a method for selectively providing voltage-gated sodium channel function sufficient to rescue impaired Nav1.1 function in inhibitory neurons. This innovation can be utilized to treat disorders such as epilepsy, with a specific focus on Dravet Syndrome.

Career Highlights

Throughout his career, Edward Sebastian Lein has worked with notable institutions, including the Allen Institute and Seattle Children's Hospital. His experience in these organizations has allowed him to advance his research and contribute to the scientific community.

Collaborations

Lein has collaborated with esteemed colleagues, including John K Mich and Jonathan Ting. These partnerships have further enriched his research endeavors and fostered innovation in his field.

Conclusion

Edward Sebastian Lein's work exemplifies the intersection of innovation and medical science. His contributions to the understanding and treatment of neurological disorders highlight the importance of research in improving patient outcomes.

Profile summary based on public USPTO records.
Data Sources: USPTO Patent Grant XML, Patent Center, EPO & CIPO • Normalized by IDiyas Innovation Graph. Methodology & provenance architecturePlease report any incorrect information to [email protected]
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