Edward L LeCluyse

Title: Edward L LeCluyse: Innovator in Hepatocyte Screening Methods

Introduction

Edward L LeCluyse is a prominent inventor based in Chapel Hill, NC (US). He has made significant contributions to the field of pharmacology, particularly in the area of drug metabolism and excretion. With a total of 3 patents, his work focuses on innovative methods for screening candidate compounds for biliary excretion.

Latest Patents

LeCluyse's latest patents include two notable methods for screening metabolites of candidate compounds. The first patent, titled "Method of screening a metabolite of a parent candidate compound for susceptibility to biliary excretion," outlines a process that involves providing a culture of hepatocytes with at least one bile canaliculus. This method allows for the exposure of a candidate compound to the culture and the determination of the amount of the compound in the bile canaliculus, indicating its susceptibility to biliary excretion. The method is particularly useful for screening multiple candidate compounds simultaneously.

The second patent, "Method of screening candidate compounds for susceptibility to biliary excretion by endogenous transport systems," shares a similar approach. It also involves the use of hepatocyte cultures and aims to determine the susceptibility of candidate compounds to biliary excretion. This method enhances the efficiency of drug screening processes.

Career Highlights

Edward L LeCluyse is affiliated with the University of North Carolina at Chapel Hill, where he continues to advance research in drug metabolism. His innovative approaches have garnered attention in the scientific community, contributing to a better understanding of how drugs are processed in the liver.

Collaborations

LeCluyse has collaborated with notable colleagues, including Kim L R Brouwer and Xingrong Liu. These partnerships have further enriched his research and expanded the impact of his work in the field.

Conclusion

Edward L LeCluyse stands out as an influential inventor in the realm of drug metabolism, with his innovative screening methods paving the way for advancements in pharmacological research. His contributions continue to shape the future of drug development and safety.