Edward A Rossi

Title: Edward A. Rossi: Innovator in Protein Expression Technologies

Introduction

Edward A. Rossi is a notable inventor based in Nutley, NJ (US). He has made significant contributions to the field of biotechnology, particularly in the area of protein expression in mammalian cells. His innovative work has implications for various applications, including the production of therapeutic proteins and vaccines.

Latest Patents

Edward A. Rossi holds a patent for "Methods for protein expression in mammalian cells in serum-free medium." This patent discloses compositions and methods aimed at increasing the longevity of cell cultures, thereby enhancing the production of proteins, especially recombinant proteins such as antibodies, peptides, enzymes, growth factors, interleukins, interferons, hormones, and vaccines. The invention involves transfecting cells with an apoptosis-inhibiting gene or vector, such as a triple mutant Bcl-2 gene, which allows these cells to survive longer in culture. This results in an extension of the state and yield of protein biosynthesis. The transfected cells can achieve maximal cell densities that equal or exceed those of the parent cell lines. Furthermore, these cells can be pre-adapted for growth in serum-free medium, significantly reducing the time required for protein production.

Career Highlights

Edward A. Rossi is associated with Immunomedics, Inc., a company that focuses on developing innovative therapeutic products for the treatment of cancer and other serious diseases. His work at Immunomedics has been instrumental in advancing the company's research and development efforts in the field of biotechnology.

Collaborations

Throughout his career, Edward has collaborated with esteemed colleagues, including David M. Goldenberg and Chien-Hsing Chang. These collaborations have contributed to the advancement of research in protein expression and therapeutic development.

Conclusion

Edward A. Rossi's contributions to the field of protein expression technologies highlight his role as an innovator in biotechnology. His patent for methods that enhance protein production in mammalian cells demonstrates the potential for significant advancements in therapeutic applications.