Duncan A Miller

Title: **Duncan A. Miller: Innovator in the Biopharmaceutical Field**

Introduction

Duncan A. Miller is a notable inventor based in Morris Township, NJ, known for his significant contributions to the biopharmaceutical industry. With a keen focus on enzyme expression, Miller has successfully developed innovative cell lines that enhance the preparation of amidated products.

Latest Patents

Miller holds a patent titled "Cell lines for expressing enzyme useful in the preparation of amidated products". This patent relates to the provision of cell lines that express peptidylglycine alpha-amidating monooxygenase (PAM) or one of its two catalytic domains. His inventive approach achieves high levels of enzyme expression while utilizing a non-animal source and a low protein tissue culture medium. The innovation features a robust two-step downstream purification process that results in high enzyme purity, with the resulting PAM or its PHM catalytic domain being used to catalyze the enzymatic conversion of X-Gly to X-alpha-hydroxy-Gly or X—NH (where X denotes a peptide or any chemical compound with a carbonyl group capable of covalently attaching a glycine group).

Career Highlights

Duncan A. Miller is currently associated with Enteris Biopharma, Inc., where he continues to contribute his expertise in biopharmaceutical innovations. His career showcases a dedication to advancing methods that can improve the efficacy and safety of pharmaceutical products.

Collaborations

Throughout his career, Miller has collaborated with esteemed colleagues such as Nozer M. Mehta and Angelo P. Consalvo. These partnerships underscore the collaborative nature of innovation within the biopharmaceutical community, fostering advancements that can lead to significant medical breakthroughs.

Conclusion

Duncan A. Miller's work exemplifies the spirit of innovation in the biopharmaceutical sector. His patented techniques in enzyme expression not only highlight his inventiveness but also contribute to the growing field of medicine, paving the way for enhanced therapeutic options. As research continues, Miller's contributions stand as a testament to the impact that dedicated inventors can have on health and science.