This inventor holds 3 USPTO granted patents. Top assignee: Alpha Therapeutic Corporation. Active years: 1995-1999.
Company Filing History:
2 out of 43 Years Active: 1995-1999
Title: Innovations by Duk Sung Hwang
Introduction
Duk Sung Hwang is a notable inventor based in South Pasadena, CA (US). He has made significant contributions to the field of protein purification, holding a total of 3 patents. His work focuses on enhancing the yield and purity of important proteins, which has implications in various medical and therapeutic applications.
Latest Patents
Hwang's latest patents include a process for increasing the yield of a protein that has been subjected to purification. This process involves providing an impure protein fraction containing alpha-1-proteinase inhibitor (alpha-1-PI). The impure fraction is suspended in an aqueous solution at pH 6, where insoluble proteins are recovered and resuspended in a solution at pH 8.5. Polyethylene glycol (PEG) is added to precipitate alpha-2 proteins, and zinc chloride (ZnCl2) is used to precipitate crude alpha-1-PI from the PEG supernatant. The crude alpha-1-PI is then resolubilized and applied to an anion-exchange medium, allowing for the recovery of a fraction comprising alpha-1-PI, which has a specific activity of about 1.0 units/OD280.
Another significant patent by Hwang is a process for separating alpha-1-proteinase inhibitor from COHN IV1. This process follows a similar methodology to his previous patent, emphasizing the purification of alpha-1-PI from impure protein fractions.
Career Highlights
Duk Sung Hwang is currently associated with Alpha Therapeutic Corporation, where he continues to innovate in the field of protein purification. His work has been instrumental in advancing therapeutic applications of proteins, particularly in the context of alpha-1-PI.
Collaborations
Hwang has collaborated with notable coworkers, including Mark Lepe and Lyndon Luz, contributing to a dynamic research environment that fosters innovation and development in protein purification techniques.
Conclusion
Duk Sung Hwang's contributions to the field of protein purification through his innovative patents highlight his expertise and commitment to advancing medical science. His work at Alpha Therapeutic Corporation and collaborations with colleagues further enhance the impact of his inventions in the industry.