Douglas S Burdette

Title: Innovations of Douglas S. Burdette

Introduction

Douglas S. Burdette is an accomplished inventor based in Monmouth Junction, NJ (US). He is known for his significant contributions to the field of biotechnology, particularly in the cloning and expression of genes related to enzyme activity.

Latest Patents

Douglas S. Burdette holds a patent for the cloning and expression of the gene encoding thermoanaerobacter. His patent details the adhB gene encoding Thermoanaerobacter ethanolicus 39E secondary-alcohol dehydrogenase, which was cloned, sequenced, and expressed in Escherichia coli. The gene, consisting of 1056 base pairs, encodes a homotetrameric recombinant enzyme with subunits of 37.7 kDa. The enzyme exhibits optimal activity above 90°C and has a half-life of approximately 1.7 hours at this temperature. Notably, the recombinant enzyme demonstrates a 1400-fold greater catalytic efficiency in propan-2-ol oxidation compared to ethanol.

Career Highlights

Douglas S. Burdette has made significant strides in enzyme research, particularly focusing on the structural and catalytic properties of secondary-alcohol dehydrogenases. His work has implications for various industrial applications, including biofuel production.

Collaborations

He has collaborated with Joseph G. Zeikus, a fellow researcher, to further explore the enzymatic properties and potential applications of the enzymes they study.

Conclusion

Douglas S. Burdette's innovative work in biotechnology and enzyme research highlights his contributions to the scientific community. His patent on the adhB gene showcases the potential for advancements in industrial applications through enzyme engineering.