Location History:
- New Haven, CT (US) (1987)
- Branford, CT (US) (2022)
Company Filing History:
Years Active: 1987-2022
Title: Innovations of Douglas L Rothman
Introduction
Douglas L Rothman is a prominent inventor based in New Haven, CT (US). He has made significant contributions to the field of medical imaging and metabolic assessment, holding 2 patents that showcase his innovative approaches.
Latest Patents
One of his latest patents is titled "Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA)." This method allows for the non-invasive assessment of rates of hepatic mitochondrial oxidation and pyruvate carboxylase flux in subjects. The PINTA method utilizes a combined NMR and gas chromatography-mass spectrometry analysis of plasma following the infusion of [3-C]lactate and glucose tracer. This invention provides researchers with a valuable tool to examine altered hepatic mitochondrial metabolism and study therapeutic interventions for conditions such as non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and type 2 diabetes (T2D).
Another notable patent is the "Apparatus and method for determining the presence of substances in a sample." This invention involves a method for unambiguously determining the presence of specific substances in a sample using NMR. The apparatus allows for high-resolution NMR imaging of these substances by employing frequency selective RF pulse sequences to excite nuclear spins and produce spin echo signals. This innovative approach enhances the ability to identify substances of interest while suppressing signals from water components in the sample.
Career Highlights
Douglas L Rothman is affiliated with Yale University, where he continues to advance research in his field. His work has significantly impacted the understanding of metabolic processes and imaging techniques.
Collaborations
He has collaborated with notable colleagues, including Malcolm J Avison and Hoby P Hetherington, contributing to the advancement of research in medical imaging and metabolism.
Conclusion
Douglas L Rothman is a distinguished inventor whose work in non-invasive metabolic assessment and imaging has paved the way for advancements in medical research. His contributions continue to influence the field and improve therapeutic strategies for various health conditions.