Location History:
- Pompton Lakes, NJ (US) (1984 - 1986)
- Concord/Boothwyn, PA (US) (2002)
- San Mateo, CA (US) (2020 - 2024)
Company Filing History:
4 out of 130 
4 out of 832,880 Years Active: 1984-2024
Title: Innovations by Douglas H Smith
Introduction
Douglas H Smith is a notable inventor based in San Mateo, California. He has made significant contributions to the field of immunology, holding a total of 8 patents. His work primarily focuses on developing antibodies that target immune checkpoints, which are crucial for regulating immune responses.
Latest Patents
Among his latest patents are the LAG-3-binding molecules and methods of use thereof. This invention is directed to anti-LAG-3 antibodies, including LAG-3 mAb 1, LAG-3 mAb 2, LAG-3 mAb 4, LAG-3 mAb 5, and LAG-3 mAb 6. It also includes humanized and chimeric versions of these antibodies. The invention pertains to LAG-3-binding molecules that comprise binding fragments of these antibodies, immunoconjugates, and bispecific molecules. These innovations are designed to stimulate immune responses and detect LAG-3 effectively.
Another significant patent is related to PD-1-binding molecules and methods of use thereof. This invention includes selected anti-PD-1 antibodies capable of binding to both cynomolgus monkey PD-1 and human PD-1. The patent covers PD-1 mAb 1 through PD-1 mAb 15, along with their humanized and chimeric versions. Similar to his LAG-3 inventions, this patent also focuses on methods for using these molecules to stimulate immune responses and detect PD-1.
Career Highlights
Douglas has worked with various companies, including Macrogenics, Inc. His experience in the biotechnology sector has allowed him to contribute to groundbreaking research and development in immunotherapy.
Collaborations
Some of his notable coworkers include Kalpana Shah and Ross La Motte-Mohs. Their collaboration has likely enhanced the innovative processes and outcomes in their respective projects.
Conclusion
Douglas H Smith's contributions to the field of immunology through his patents and collaborations highlight his role as a significant inventor. His work continues to influence the development of therapies that target immune checkpoints, showcasing the importance of innovation in medical science.