Company Filing History:
Years Active: 1998-1999
Title: Douglas F. Kline: Innovating Stability in Interferon Solutions
Introduction
Douglas F. Kline, an accomplished inventor based in Hoboken, NJ, has made significant contributions to the field of pharmaceuticals with his two patented innovations. His work focuses on enhancing the stability of interferon formulations, crucial for their efficacy and shelf-life.
Latest Patents
Kline's latest patents revolve around the development of stable aqueous alfa interferon solution formulations. These formulations include various components designed to maintain stability over extended periods. The patents disclose compositions that contain alfa-type interferon, specifically interferon alfa-2a and interferon alfa-2b. A critical aspect of these formulations is a buffer that maintains a pH in the range of 4.5-7.1, alongside polysorbate 80 as a stabilizer, edetate disodium as a chelating agent, sodium chloride for tonicity, and m-cresol as an antimicrobial preservative. These innovations aim to ensure the high chemical, physical, and biological stability of alfa-type interferon, maintaining its efficacy for at least 24 months during storage.
Career Highlights
Douglas F. Kline has had a noteworthy career, particularly while working with Schering Corporation, a leader in pharmaceutical development. His expertise in formulating stable medicinal products has positioned him as a key player in the industry. Kline's contributions are vital for enhancing the available treatment options for patients requiring alfa interferon therapies.
Collaborations
In his endeavors, Kline has collaborated with fellow innovator Pui-Ho C. Yuen. Together, they have successfully advanced the understanding and application of interferon solutions, making strides in how these vital medications can be stabilized and used more effectively in clinical settings.
Conclusion
Douglas F. Kline stands out as a significant inventor in the pharmaceutical industry, particularly known for his work with stable alfa interferon solution formulations. His patents reflect a commitment to improving the storability and effectiveness of crucial therapeutic proteins, demonstrating the importance of innovation in the field of medicine.