Douglas Auld

Title: Innovations by Inventor Douglas Auld in the Field of Pharmacology

Introduction

Douglas Auld, based in Cranbury, NJ, is an innovative inventor with a remarkable contribution to the field of pharmacology. He holds three patents that focus on methods to measure enzymatic activities that are crucial for therapeutic advancements. His work is particularly relevant in high-throughput screening and drug discovery processes.

Latest Patents

Auld's latest patents include groundbreaking methods that enhance the understanding of phosphatase and kinase activities. One such patent, titled "Methods for measuring phosphatase activity," presents a revolutionary approach to determining enzyme activity without relying on antibodies or radioactive labels. This method utilizes a fluorescently-labeled phosphorylatable reporter peptide, which can be cleaved by a protease exclusively when it remains in an unphosphorylated state. Changes in fluorescence characteristics indicate the level of protease cleavage, thereby offering a direct measure of phosphatase activity while suggesting an inverse relationship with kinase activity. This method is especially beneficial for high-throughput screening, enabling the identification of compounds that can modulate these types of enzymatic activities.

Another notable patent is "Orthologues of human receptors and methods of use," which describes innovative methods for identifying modulators of receptor activity using orthologues from various mammalian species. This patent includes the cloning and characterization of genes for bradykinin receptors across species such as the vervet monkey, rhesus macaque, tree shrew, dog, and pig, as well as CXCR2 receptors from chimpanzee, gorilla, orangutan, and other primates. These advancements are critical in effectively screening potential therapeutic agents.

Career Highlights

Douglas Auld is associated with Pharmacopeia Drug Discovery, Inc., where he contributes his extensive knowledge and expertise in drug discovery and enzymatic activity measurement. His innovative ideas have significantly advanced the methodologies used in pharmacological research, positioning him as a valuable asset in the industry.

Collaborations

Throughout his career, Auld has collaborated with notable colleagues such as Robert A. Horlick and Jiuquao Zhao. These partnerships have fostered a productive research environment, facilitating the development of advanced methods and technologies in drug discovery.

Conclusion

Inventor Douglas Auld's contributions through his patented innovations serve as a testament to his commitment to enhancing pharmacological research. His work at Pharmacopeia Drug Discovery, Inc. exemplifies the potential of innovative methodologies in identifying new therapeutic agents and advancing drug discovery processes.