Company Filing History:
Years Active: 1993-1994
Title: Donia L Henderson: Innovator in Taxane Yield Enhancement
Introduction
Donia L Henderson is a prominent inventor based in Boulder, Colorado. She has made significant contributions to the field of biotherapeutics, particularly in the enhancement of taxane yields. With a total of three patents to her name, her work is paving the way for advancements in this important area of research.
Latest Patents
One of her latest patents is a method of using ion exchange media to increase taxane yields. This innovative method employs an absorption column for the cleavage and recovery of taxanes, which are typically not detected as free taxanes. The process begins with loading a column with ion exchange media and placing a first solution containing standard detectable taxanes and other undetectable taxane compounds into the column. As the solution passes through the ion exchange media, taxane compounds are converted to standard taxanes, resulting in a second solution with a higher percentage of detectable standard taxanes. The ion exchange media utilized in this method is an ion exchange resin, which can be a mixture of anion and cation exchange resins, preferably alumina.
Another notable patent involves processes for converting taxanes into 10-deacetylbaccatin III. This process includes contacting a mixture containing at least one taxane compound with a borohydride reducing salt in the presence of a Lewis acid, showcasing her innovative approach to biochemistry.
Career Highlights
Donia L Henderson is currently employed at Napro Biotherapeutics, Inc., where she continues to develop her groundbreaking research. Her work is instrumental in advancing the understanding and application of taxanes in therapeutic settings.
Collaborations
Throughout her career, she has collaborated with notable colleagues, including David Reginald Carver and Timothy R Prout. These partnerships have further enriched her research and contributed to her success in the field.
Conclusion
Donia L Henderson is a trailblazer in the field of biotherapeutics, with her innovative methods for enhancing taxane yields. Her contributions are vital to the ongoing research and development in this area, and her work continues to inspire future innovations.