Company Filing History:
Years Active: 2024-2025
Title: Innovations of Donghan Ma in Nanoscopy
Introduction
Donghan Ma is a prominent inventor based in West Lafayette, IN (US). He has made significant contributions to the field of nanoscopy, particularly in the area of pinpointing single molecule positions. His innovative methods have advanced the capabilities of imaging techniques used in biological research.
Latest Patents
Donghan Ma holds 2 patents that focus on in situ point spread function (PSF) retrieval for three-dimensional nanoscopy of whole cells and tissues. His first patent describes a method that encodes the 3D location of molecules into PSFs. This involves receiving molecule-generated images containing PSFs, segmenting the images into sub-PSFs, and initializing template PSFs from a pupil function. The process includes determining a statistical measure of a predetermined function between the sub- and template PSFs, aligning and averaging the sub-PSFs, and applying a phase retrieval algorithm to update the pupil function. The method continues until a difference between the new and prior generation pupil function is below a predetermined threshold, ultimately generating lateral and axial locations of molecules.
His second patent also focuses on in situ PSF retrieval, detailing a method that includes determining a maximum normalized cross-correlation (NCC) coefficient between the sub- and template PSFs. This method associates each of the sub-PSFs with a template PSF based on the NCCmax, storing the sub-PSFs in associated bins, and applying a maximum likelihood estimation algorithm to generate the locations of molecules.
Career Highlights
Donghan Ma is affiliated with the Purdue Research Foundation, where he continues to develop his innovative techniques in nanoscopy. His work has been instrumental in enhancing the precision of molecular imaging, which is crucial for various applications in biological sciences.
Collaborations
Some of his notable coworkers include Fan Xu and Fang Huang, who have collaborated with him on various research projects.
Conclusion
Donghan Ma's contributions to the field of nanoscopy through his innovative patents have significantly advanced the understanding of molecular imaging. His work continues to inspire further research and development in this critical area of science.