Dong Li

Title: Innovations of Dong Li in Antibody Preparation

Introduction

Dong Li is a prominent inventor based in Lanzhou, China. He has made significant contributions to the field of antibody preparation, particularly in developing methods to combat foot-and-mouth disease virus. His innovative approach has the potential to enhance the effectiveness of vaccines and treatments for this viral infection.

Latest Patents

Dong Li holds a patent titled "Method for preparing whole bovine-derived broadly neutralizing antibody against serotype O foot-and-mouth disease virus." This invention relates to a method for preparing a whole bovine-derived broadly neutralizing antibody against the serotype O foot-and-mouth disease virus, which belongs to the technical field of antibody preparation. The method includes several steps: conducting immunization on cattle, screening for serotype O foot-and-mouth disease virus antigen-specific single B cells, amplifying variable region genes of the heavy and light chains, acquiring constant region sequences of the heavy and light chains, preparing a full-length heavy chain vector, co-transfecting a cell, taking the supernatant of cell culture, and purifying. This method utilizes different foot-and-mouth disease virus strains to infect cattle and obtain a neutralizing antibody capable of neutralizing three topotypes of serotype O FMDVs by screening, thus leading to the development of a whole bovine-derived broadly neutralizing monoclonal antibody.

Career Highlights

Dong Li is affiliated with the Chinese Academy of Agricultural Sciences, where he conducts his research and development activities. His work focuses on innovative methods to enhance the production of antibodies that can effectively neutralize viral infections.

Collaborations

Dong Li collaborates with notable colleagues, including Yimei Cao and Xingwen Bai, who contribute to his research efforts in the field of antibody preparation.

Conclusion

Dong Li's innovative methods in antibody preparation represent a significant advancement in the fight against foot-and-mouth disease virus. His contributions are vital for improving public health and agricultural practices.