Company Filing History:
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Years Active: 2002-2021
Title: The Innovative Contributions of Donald O'Rourke
Introduction
Donald O'Rourke is a notable inventor based in Wynnewood, Pennsylvania. He has made significant contributions to the field of medical imaging and oncology, particularly in the diagnosis and treatment of glioblastoma. With a total of four patents to his name, O'Rourke's work has the potential to impact patient care and treatment outcomes.
Latest Patents
One of O'Rourke's latest patents is focused on the in vivo detection of epidermal growth factor receptor (EGFR) mutation status in glioblastoma via MRI signature consistent with deep peritumoral infiltration. This method involves performing quantitative pattern analysis of MRI data to determine the level of spatial heterogeneity or similarity within the peritumoral edematous tissue of a patient. Based on this analysis, EGFR mutation status is assigned as either negative or positive. Additionally, he has developed methods and compositions for the diagnosis of glioblastoma or its subtypes. This includes an isoform-level gene panel that accurately classifies glioblastoma subtypes from tumor samples, utilizing reagents for detecting the expression or activity of target isoforms.
Career Highlights
O'Rourke has had a distinguished career, working with prestigious institutions such as the University of Pennsylvania and The Wistar Institute of Anatomy & Biology. His research has focused on advancing the understanding and treatment of glioblastoma, contributing to the development of innovative diagnostic tools.
Collaborations
Throughout his career, O'Rourke has collaborated with esteemed colleagues, including Mark I Greene and Ramachandran Murali. These collaborations have further enhanced the impact of his research and innovations in the field.
Conclusion
Donald O'Rourke's contributions to medical imaging and oncology exemplify the importance of innovation in improving patient outcomes. His patents and research continue to pave the way for advancements in the diagnosis and treatment of glioblastoma.