Location History:
- Bedford, MA (US) (1992)
- Scituate, MA (US) (1992)
Company Filing History:
Years Active: 1992
Title: The Innovations of Donald A. Colbert
Introduction
Donald A. Colbert is a notable inventor based in Bedford, MA (US). He has made significant contributions to the field of biotechnology, particularly in the area of recombinant proteins. With a total of 2 patents, his work has had a substantial impact on diagnostic test systems and agricultural biotechnology.
Latest Patents
Colbert's latest patents include groundbreaking innovations. The first patent involves the cloning of genes encoding recombinant protein A. This gene coding for a protein A-like material has been successfully cloned and expressed for the first time. The cloning of this gene, along with its nucleotide sequence characterization, enables skilled professionals to obtain quantities of a protein A-like material nucleotide sequence for cloning in various host-vector systems. Protein A is well known as a valuable component of a variety of diagnostic test systems. The protein A-like material of this invention, and its subfragments, possess the properties of binding to IgG at the Fc region and activating polyclonal antibody synthesis. Thus, these entities are useful in the same manner as protein A.
The second patent pertains to activated Bacillus thuringiensis delta-endotoxin produced by a novel hybrid gene. This gene is cloned into a novel plasmid, which is transformed into a prokaryotic host. The delta-endotoxin of this invention is active against Lepidoptera larvae, showcasing its potential in agricultural applications.
Career Highlights
Colbert has had a distinguished career, working at Repligen Corporation, where he has been able to apply his innovative ideas in a practical setting. His work has contributed to advancements in biotechnology and has positioned him as a key figure in his field.
Collaborations
Throughout his career, Colbert has collaborated with notable colleagues, including Algis Anilionis and Daniel P. Witt. These collaborations have further enhanced his research and development efforts.
Conclusion
Donald A. Colbert's contributions to biotechnology through his patents and work at Repligen Corporation highlight his role as an influential inventor. His innovations in recombinant proteins and agricultural biotechnology continue to pave the way for future advancements in these fields.