Don Kuehl

Title: Innovations by Don Kuehl: Advancements in Chromatography and Mass Spectrometry

Introduction: Don Kuehl, an innovative inventor based in Windham, NH, has made notable contributions to the field of analytical chemistry. With an impressive total of two patents, Kuehl's work has significantly enhanced the methodologies used in chromatography and mass spectral analysis, showcasing his dedication to advancing scientific research.

Latest Patents: Don Kuehl's latest patents include groundbreaking technologies that improve both the reliability and automation of spectral analysis.

1. **Direct and Automatic Chromatography-Mass Spectral Analysis**: This method provides a comprehensive approach to acquiring spectral data from samples. It involves detecting the presence of compounds within a specified time window, conducting spectral library searches, evaluating hit lists, and performing regression analysis to identify and refine the accuracy of compound retention times. This patent allows for the identification of compounds with a calculated retention index value used as a filtering metric to assess the likelihood of identification.

2. **Reliable and Automatic Mass Spectral Analysis**: This patent revolves around a method and mass spectrometer for acquiring raw mass spectral data. It performs multivariate statistical analysis to determine compounds, computes pure mass spectra based on separation time profiles, and generates distance measures between known and unknown samples. These advancements facilitate a more efficient identification process of unknown samples.

Career Highlights: Kuehl is currently affiliated with Cerno Bioscience LLC, where he applies his patents to improve the company's analytical capabilities. Through his innovative work, he continues to push the boundaries of what's possible in analytical chemistry, helping to pave the way for more efficient and effective research methodologies.

Collaborations: Throughout his career, Don has had the opportunity to work alongside notable colleagues, including Stacey Simonoff and Yongdong Wang. Their combined expertise has fostered a collaborative environment that promotes innovation and enhances the company's projects, underscoring the importance of teamwork in advancing scientific research.

Conclusion: Don Kuehl's contributions to the fields of chromatography and mass spectrometry represent the importance of innovation in scientific research. Through his patents, Kuehl has made strides in ensuring reliable and automated processes in mass spectral analysis, benefiting researchers and industries that rely on precise analytical techniques. His work exemplifies the pivotal role inventors play in driving progress within the scientific community.