Location History:
- Anderson, TX (US) (2016)
- Rougemont, NC (US) (2014 - 2017)
- Durham, NC (US) (2019 - 2022)
Company Filing History:
Years Active: 2014-2022
Title: **Innovations of Don Healey: Pioneering Mature Dendritic Cell Technologies**
Introduction
Don Healey, an innovative inventor based in Rougemont, North Carolina, has made significant contributions to the field of immunology through his five patented inventions. His work primarily revolves around enhancing immune responses by developing methods to prepare and use immunostimulatory cells, notably mature dendritic cells.
Latest Patents
One of Don Healey's latest patents is for "Mature dendritic cell compositions and methods for culturing same." This invention details a sophisticated approach to preparing mature dendritic cells (DCs) that enhances immune responses. The method involves a two-step signaling process, where isolated immature dendritic cells (iDCs) are first signaled with an interferon gamma receptor (IFN-γR) agonist and/or tumor necrosis factor alpha receptor (TNF-αR) agonist to produce signaled dendritic cells. Subsequently, these signaled DCs are exposed to a transient signal administering a CD40 agonist which yields CCR7 mature dendritic cells. The enriched populations of dendritic cells derived from this method exhibit enhanced immunostimulatory properties, demonstrated by increased IL-12 secretion and decreased IL-10 secretion.
Career Highlights
Throughout his career, Don Healey has worked with notable companies in the biomedical field, including Argos Therapeutics, Inc. and Coimmune, Inc. His efforts in these organizations have contributed to advancements in therapeutic techniques and cell culture methodologies that hold promise for improving patient outcomes.
Collaborations
In addition to his innovative work, Don Healey has collaborated with esteemed coworkers such as Irina Tcherepanova and Melissa Adams. Together, they have shared insights and expertise that have enriched the development of groundbreaking immunological technologies and strategies.
Conclusion
Don Healey stands out as a prominent inventor in the field of immunology, with a focus on developing mature dendritic cell cultures that could revolutionize therapeutic applications. His work not only showcases the potential of immunostimulatory cells but also underlines the importance of collaboration among pioneering scientists in pushing the boundaries of medical innovation.