Dominick J Blasioli

Title: Innovations by Dominick J Blasioli

Introduction

Dominick J Blasioli is an accomplished inventor based in Chelmsford, MA (US). He has made significant contributions to the field of pharmaceutical formulations, particularly in the development of non-injectable hydrogel technologies. With a total of two patents to his name, Blasioli's work focuses on innovative solutions for drug delivery systems.

Latest Patents

Blasioli's latest patents include groundbreaking formulations that enhance the delivery of therapeutic agents. One notable patent is for non-injectable hydrogel formulations designed for smart release. This formulation utilizes self-assembling hydrogels made from Generally Regarded as Safe (GRAS) compounds, such as ascorbyl palmitate. It can be administered in various forms, including capsules, tablets, oral suspensions, and suppositories. The formulation is particularly effective in delivering anti-inflammatories and anti-infectives, allowing for lower blood levels of the agent while maintaining therapeutic efficacy.

Another significant patent focuses on the formulation of nanostructured gels that provide high agent loading and adhesion. This gel formulation is capable of encapsulating a wide range of agents, especially amine-containing compounds like local anesthetics, which are typically challenging to encapsulate. By tuning the ionic strength of the aqueous medium during preparation, Blasioli's formulation achieves optimal agent loading and adhesion to charged surfaces, mimicking inflamed tissue.

Career Highlights

Blasioli is currently associated with Alivio Therapeutics, Inc., where he continues to innovate in the field of drug delivery systems. His work has the potential to revolutionize how medications are administered, improving patient outcomes and enhancing therapeutic effectiveness.

Collaborations

Throughout his career, Blasioli has collaborated with notable professionals in the field, including Derek G Van Der Poll and Gregory T Zugates. These collaborations have contributed to the advancement of his research and the successful development of his patented technologies.

Conclusion

Dominick J Blasioli's contributions to pharmaceutical innovations through his patented hydrogel formulations demonstrate his commitment to improving drug delivery systems. His work not only addresses current challenges in the field but also paves the way for future advancements in therapeutic applications.