Company Filing History:
Years Active: 2015-2018
Title: Innovations by Doaa Boshra Farag
Introduction
Doaa Boshra Farag is an accomplished inventor based in Cairo, Egypt. She has made significant contributions to the field of biochemistry, particularly in the development of non-peptidic inhibitors targeting specific protein domains. Her work has led to the filing of two patents, showcasing her innovative approach to scientific challenges.
Latest Patents
One of her latest patents is focused on fragment ligated inhibitors selective for the polo box domain of PLK1. This patent describes methods for developing non-peptidic inhibitors that target the polo-box domain of PLK1 proteins. The methods include developing structure-activity relationships for peptidic inhibitors, followed by the development of non-peptide fragment alternatives for portions of the peptide inhibitors. The non-peptide fragment can provide a similar structure-activity relationship as the replaced peptide. Fragment alternatives to key binding determinants are identified through an iterative computational and synthetic process, which is facilitated by an understanding of the peptide structure-activity relationships. The approach is informed by peptide structure-activity data obtained through the synthesis and testing of truncated and mutated analogs of known PBD binding motifs.
Career Highlights
Doaa Boshra Farag is currently affiliated with the University of South Carolina, where she continues her research and innovation in the field of biochemistry. Her work has garnered attention for its potential applications in therapeutic development.
Collaborations
Doaa collaborates with Campbell McInnes, who is also involved in research and development in related fields. Their partnership enhances the scope and impact of their scientific endeavors.
Conclusion
Doaa Boshra Farag's contributions to the field of biochemistry through her innovative patents and collaborations highlight her role as a leading inventor. Her work continues to pave the way for advancements in therapeutic development.
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