Location History:
- Blarney, IE (2010 - 2018)
- County Cork, IE (2006 - 2019)
Company Filing History:
5 out of 6 
4 out of 95 
1 out of 54 
Years Active: 2006-2024
Title: Innovations of Dmitri Boris Papkovsky
Introduction
Dmitri Boris Papkovsky is a notable inventor based in Blarney, Ireland. He has made significant contributions to the field of biochemistry and cellular biology, particularly in the development of methods for monitoring oxygen levels in live mammalian cells. With a total of nine patents to his name, his work has advanced the understanding of cellular metabolism and oxygen sensing.
Latest Patents
Papkovsky's latest patents focus on innovative methods and probes for monitoring oxygen status in live mammalian cells. One of his inventions involves a method of determining oxygen concentration and metabolic activity using a photoluminescence quenching technique. This technique employs a photoluminescent probe that self-loads into the cells without the need for any loading reagent. The probe consists of polymeric particles that have an amphiphilic cationic polymer matrix, featuring a hydrophobic core and a hydrophilic positively charged surface. The hydrophobic core contains an oxygen-sensitive photoluminescent dye, which allows for the detection of oxygen levels within the cells.
Another patent by Papkovsky describes a photoluminescent probe designed for intracellular sensing of oxygen. This probe comprises a suspension of polymeric particles with an average diameter ranging from 20 nm to 100 nm. The particles are formed from an amphiphilic cationic co-polymer that creates a hydrophobic core and a hydrophilic shell. The probe includes a hydrophobic oxygen-sensitive photoluminescent dye, such as Pt-tetrakis(pentafluorophenyl)porphine, embedded in the hydrophobic core. This innovative approach allows for the passive loading of the probe into live mammalian cells, enabling the sensing of oxygen by detecting the photoluminescent signal.
Career Highlights
Throughout his career, Dmitri Boris Papkovsky has worked with various organizations, including Luxcel Biosciences Limited and University College Cork. His expertise in biochemistry and cellular biology has led to numerous advancements in the field, particularly in the area of oxygen sensing technologies.
Collaborations
Papkovsky has collaborated with notable individuals in his field, including Richard Fernandes and Andreas Fercher. These collaborations have contributed to the development of innovative technologies and methodologies in cellular research.
Conclusion
Dmitri Boris Papkovsky is a distinguished inventor