Dirk J E Opstelten

Title: Innovations of Dirk J E Opstelten

Introduction

Dirk J E Opstelten is a notable inventor based in Oegstgeest, Netherlands. He has made significant contributions to the field of biotechnology, particularly in the production of recombinant proteins. With a total of four patents to his name, his work focuses on enhancing the sialylation of proteins, which is crucial for their efficacy and stability.

Latest Patents

Opstelten's latest patents include methods to obtain recombinant proteins with increased sialylation from cells that express adenovirus E1A protein. One of his notable inventions involves compositions comprising isoforms of erythropoietin (EPO) that have glycans linked thereto. These glycans possess Lewis x structures and contain an average of at least six sialic acid moieties per EPO molecule. The methods he developed include culturing eukaryotic cells containing nucleic acid sequences encoding both adenoviral E1A protein and EPO, along with a sialyltransferase, to enhance the sialic acid content of the N-linked glycans in the produced EPO.

Career Highlights

Dirk J E Opstelten is associated with Crucell Holland B.V., where he continues to innovate in the field of recombinant protein production. His work has implications for therapeutic applications, particularly in the treatment of anemia through enhanced EPO formulations.

Collaborations

Opstelten collaborates with Alphonsus G C M UytdeHaag, contributing to advancements in their shared field of research.

Conclusion

Dirk J E Opstelten's contributions to biotechnology through his patents and work at Crucell Holland B.V. highlight the importance of innovation in the production of therapeutic proteins. His research continues to pave the way for improved medical treatments.