Dino De Angelis

Title: Innovations of Dino De Angelis

Introduction

Dino De Angelis is a prominent inventor based in New York, NY (US). He has made significant contributions to the field of cellular biology through his innovative inventions. With a total of 2 patents, his work focuses on the development of hybrid molecules that enhance the understanding of cellular microenvironments.

Latest Patents

Dino De Angelis's latest patents include groundbreaking methods and compositions that utilize light emission to monitor changes in cellular microenvironments. These inventions are particularly useful for observing exocytotic activity, such as the quantal release of synaptic vesicles. His work involves fusion proteins of Cypridina luciferase and synaptotagmin-I or VAMP/synaptobrevin-2, which are targeted to synaptic vesicles. Upon exocytosis, these proteins form light-emitting complexes with luciferin present in the extracellular medium. The systems allow for the observation of photon emissions in response to depolarizing stimuli. Additionally, he has developed pH-sensitive mutants of green fluorescent protein, which are valuable for visualizing exocytosis and measuring the pH of intracellular compartments.

Career Highlights

Dino De Angelis is affiliated with the Memorial Sloan Kettering Cancer Center, where he continues to advance his research and innovations. His work has garnered attention for its potential applications in understanding cellular processes and disease mechanisms.

Collaborations

Dino has collaborated with notable scientists, including James Edward Rothman and Gero Miesenböck, contributing to the advancement of knowledge in the field of cellular biology.

Conclusion

Dino De Angelis is a distinguished inventor whose work in hybrid molecules and cellular microenvironments has the potential to revolutionize our understanding of cellular activities. His contributions to science are invaluable and continue to inspire future innovations.