Company Filing History:
Years Active: 2019-2023
Title: Innovations of Dimitri Michael Kullmann
Introduction
Dimitri Michael Kullmann is a prominent inventor based in London, GB. He has made significant contributions to the field of neuroscience through his innovative patents. With a total of three patents to his name, Kullmann's work focuses on advancing treatments for neurological disorders.
Latest Patents
Kullmann's latest patents include groundbreaking inventions aimed at improving the treatment of epilepsy and similar neurological conditions. One of his notable inventions is related to expression vectors comprising engineered genes. This invention provides expression vectors, nucleic acids, vector particles, and methods of treatment involving these vector particles, which include an engineered KCNA1 gene encoding an edited Kv1.1 potassium channel. The features of the engineered KCNA1 gene enhance the translation and activity of the Kv1.1 protein, improving the detection of KCNA1 gene expression in a cell. This technology can be utilized in the treatment of epilepsy and other neurological disorders.
Another significant patent involves the combined use of a vector encoding a modified receptor and its exogenous agonist in the treatment of seizures. This invention provides methods and materials for treating seizure disorders such as epilepsy. It employs a vector encoding a modified receptor, known as the 'DREADD' receptor, characterized by a decreased responsiveness to its endogenous activating ligand while retaining or enhancing responsiveness to an exogenous agonist. The modified receptor is expressed in neurons of a seizure focus in the patient's brain, and the administration of an exogenous agonist activates the modified receptor, leading to altered excitability of the neurons and potential inhibition of seizures.
Career Highlights
Dimitri Michael Kullmann is associated with UCL Business Plc, where he continues to develop his innovative ideas. His work has garnered attention in the scientific community, contributing to advancements in the treatment of neurological disorders.
Collaborations
Kullmann collaborates with esteemed colleagues, including Stephanie Schorge and Matthew Charles Walker. Their combined expertise enhances the research and development of innovative solutions in the field of neuroscience.
Conclusion
Dimitri Michael Kullmann's contributions to the field of neuroscience through his patents demonstrate his commitment to improving treatments for neurological disorders. His innovative approaches have the potential to significantly impact the lives of individuals affected by these conditions.