Location History:
- St. Louis, MO (US) (1997 - 2002)
- St. Louis, MI (US) (2004)
Company Filing History:
8 out of 17 
1 out of 832,912 Years Active: 1997-2004
Title: Dikla Roufa: Innovator in Biocompatible Anionic Polymers
Introduction
Dikla Roufa is a prominent inventor based in St. Louis, MO (US), known for her significant contributions to the field of biocompatible anionic polymers. With a total of nine patents to her name, she has made remarkable strides in developing methods and compositions that inhibit cell invasion and fibrosis.
Latest Patents
Her latest patents focus on the discovery that biocompatible anionic polymers can effectively inhibit fibrosis, scar formation, and surgical adhesions. The invention is based on the understanding that the effectiveness of anionic polymers in inhibiting cell invasion correlates with the anionic charge density of the polymer. This innovation provides a wide range of materials for use in methods aimed at inhibiting fibrosis and fibroblast invasion. The anionic polymers utilized in her inventions include natural proteoglycans, glycosaminoglycan moieties, anionic carbohydrates, and other anionic polymers. Notably, dextran sulfate and pentosan polysulfate are preferred, with dextran sulfate being particularly effective when its sulfur content exceeds 10% by weight and has an average molecular weight ranging from 40,000 to 500,000 Daltons. These compositions and methods are designed to inhibit fibrosis and scarring associated with surgical procedures, as well as to prevent glial cell invasion, detrimental bone growth, and neurite outgrowth.
Career Highlights
Throughout her career, Dikla Roufa has worked with various companies, including Gliatech, Inc. Her innovative work has positioned her as a key figure in the development of medical solutions that address significant health challenges.
Collaborations
Dikla has collaborated with notable individuals in her field, including Adrian Harel and George T. Coker, III. These partnerships have contributed to her success and the advancement of her research.
Conclusion
Dikla Roufa's work in the field of biocompatible anionic polymers showcases her dedication to innovation and improving medical outcomes. Her patents reflect a commitment to addressing critical issues in healing processes, making her a significant contributor to the field.