Dieter Klein

Title: Dieter Klein: Innovator in Gene Therapy

Introduction

Dieter Klein is a prominent inventor based in Tulln, Austria. He has made significant contributions to the field of gene therapy, particularly through his innovative work with retroviral vectors. With a total of 3 patents, Klein's inventions are paving the way for advancements in targeted gene expression and therapy.

Latest Patents

Klein's latest patents include a groundbreaking invention titled "Reconstituting retroviral vector (recon vector) for targeted gene expression." This invention relates to a retroviral vector that serves as a safe gene transfer vehicle for targeted gene therapy. The vector comprises one or more promoters inserted in antisense orientation within the 5′ LTR region and one or more coding sequences inserted in antisense orientation within the 3′ LTR region. This design ensures that both the promoter and the coding sequence are duplicated during reverse transcription in a target cell, allowing for effective gene expression without external stimuli. Another notable patent is "Targeted integration into chromosomes using retroviral vectors," which encodes heterologous genes for gene therapy aimed at treating genetic defects or viral infections.

Career Highlights

Throughout his career, Dieter Klein has worked with esteemed organizations such as Bavarian Nordic Research Institute A/S and Institut für Virologie. His work has been instrumental in advancing the understanding and application of gene therapy techniques.

Collaborations

Klein has collaborated with notable professionals in his field, including Brian Salmons and Ralf Steinborn. These partnerships have contributed to the success and impact of his inventions.

Conclusion

Dieter Klein's innovative work in gene therapy exemplifies the potential of retroviral vectors in medical applications. His contributions are significant in the ongoing quest for effective treatments for genetic disorders and viral infections.