Derrick R Witcher

Title: Derrick R Witcher: Innovator in Immunogenic Research

Introduction

Derrick R Witcher is a notable inventor based in Coralville, IA (US). He has made significant contributions to the field of immunogenic research, particularly through his innovative work on ryanodine derivatives. His research has implications for the development of high-affinity antibodies, which are crucial for various biomedical applications.

Latest Patents

Derrick R Witcher holds a patent for an "Immunogenic ryanodine derivative and related uses." This patent discloses a novel photo-activatable derivative of ryanodine, specifically 9-hydroxy-21-(4-azidobenzoyloxy)-9-epiryanodine. The derivative has been conjugated to keyhole limpet hemocyanin (KLH) to produce antibodies with high affinity and specificity to ryanodine. A radioimmunoassay specific for ryanodine was developed using these antibodies, achieving a dissociation constant for ryanodine of 1 nM. Additionally, the binding of a labeled, photoactivatable derivative of ryanodine with the ryanodine receptor of skeletal, cardiac, and brain membranes was also disclosed.

Career Highlights

Derrick R Witcher is affiliated with the University of Iowa Research Foundation, where he continues to advance his research in immunogenic derivatives. His work has garnered attention for its potential applications in medical diagnostics and therapeutics.

Collaborations

Derrick has collaborated with notable colleagues such as Kevin P Campbell and Peter McPherson, contributing to a rich environment of innovation and research.

Conclusion

Derrick R Witcher is a prominent figure in the field of immunogenic research, with a focus on ryanodine derivatives. His innovative work and collaborations have the potential to impact various biomedical fields significantly.