Company Filing History:
Years Active: 2015-2017
Title: The Innovations of Derek John Hook
Introduction
Derek John Hook is a notable inventor based in San Diego, CA. He has made significant contributions to the field of tauopathy research, holding 2 patents that focus on innovative compositions and methods related to this condition. His work is crucial in advancing the understanding and treatment of tauopathies, which are neurodegenerative diseases associated with tau protein abnormalities.
Latest Patents
Derek's latest patents include compositions and methods related to tauopathy. These patents disclose isolated polypeptides, antibody preparations, treatment methods, diagnostic methods, and screening methods. The isolated polypeptide generally includes a core pentapeptide, with the stipulation that it is not a native full-length tau protein. The antibody preparations are designed to specifically bind to SEQ ID NO:12. The treatment methods involve administering a composition that includes the isolated polypeptide to a subject. Furthermore, the diagnostic methods entail contacting a sample from a subject with an antibody preparation that specifically binds to SEQ ID NO:12, followed by detecting a ligand in the sample that binds to the antibody preparation. The screening method includes incubating a mixture of caspase-2, a labeled caspase-2 cleavage substrate, and a test compound under conditions that allow the caspase-2 to cleave the substrate, determining whether the test compound inhibits this cleavage.
Career Highlights
Derek John Hook is affiliated with the University of Minnesota, where he continues to engage in groundbreaking research. His work has positioned him as a key figure in the study of tauopathies, contributing to the development of potential therapeutic strategies.
Collaborations
Derek collaborates with esteemed colleagues such as Karen Hsiao Ashe and Xiaohui Zhao. Their combined expertise enhances the research efforts in the field of tauopathy, fostering innovation and discovery.
Conclusion
Derek John Hook's contributions to tauopathy research through his patents and collaborations highlight his role as an influential inventor. His work is paving the way for advancements in understanding and treating neurodegenerative diseases.