Location History:
- Pittsburg, PA (US) (2018)
- Pittsburgh, PA (US) (2021 - 2023)
Company Filing History:
Years Active: 2018-2023
Title: Innovations in Sepsis Research by Derek Angus
Introduction
Derek Angus is a prominent inventor based in Pittsburgh, PA, known for his significant contributions to the field of sepsis research. With a total of three patents, his work focuses on identifying proteomic biomarkers that can help in understanding age-related sepsis risk in patients.
Latest Patents
Angus's latest patents include groundbreaking research on proteomic biomarkers of sepsis in both young and elderly patients. His first patent discloses a proteomic expression platform designed to identify age-related sepsis risk using patients with intra-abdominal infections. This innovative approach employs a semi-quantitative plasma proteomics workflow that incorporates tandem immuno affinity depletion, iTRAQ labeling, strong cation exchange fractionation, and nanoflow-liquid chromatography coupled to high-resolution mass spectrometry. The resulting protein profile reveals statistically significant differences in expression levels among patients with severe sepsis, highlighting pathways such as acute phase response, coagulation signaling, atherosclerosis signaling, lipid metabolism, and the production of nitric oxide/reactive oxygen species.
The second patent mirrors the first, focusing on elderly patients and utilizing the same advanced proteomic techniques to uncover critical insights into sepsis risk as a function of age. This research is vital for developing targeted therapies and improving patient outcomes.
Career Highlights
Derek Angus is affiliated with the University of Pittsburgh, where he continues to advance his research in sepsis and related fields. His work has garnered attention for its potential to transform clinical practices and enhance patient care.
Collaborations
Angus collaborates with esteemed colleagues, including John A. Kellum and Zhiyun Cao, who contribute to the multidisciplinary approach necessary for tackling complex medical challenges.
Conclusion
Derek Angus's innovative research in proteomic biomarkers of sepsis represents a significant advancement in understanding and treating this critical condition. His contributions are paving the way for improved diagnostic and therapeutic strategies in sepsis management.