Location History:
- Winchester, MA (US) (2003 - 2021)
- Cambridge, MA (US) (2021)
Company Filing History:
8 out of 15 
6 out of 2,893 
2 out of 1,209 
Years Active: 2003-2025
Title: Innovation and Impact: The Patents of Dennis Sgroi
Introduction
Dennis Sgroi, an accomplished inventor based in Winchester, MA, has made significant contributions to the field of cancer research through his innovative patents. With a total of 11 patents to his name, Sgroi has focused on the identification and application of gene expression profiles that hold clinical relevance for breast cancer prognosis and tumor grading.
Latest Patents
Sgroi's latest innovations include two pivotal patents that highlight his work in cancer prognosis. The first, “Post-treatment Breast Cancer Prognosis,” details the identification and use of specific gene expression profiles that correlate with extended treatment success and cancer-free survival. This patent discloses the identities of genes that indicate a patient's benefit from a switch in endocrine therapy. It provides a molecular index for predicting clinical outcomes, recurrence of cancer, and the likelihood of metastasis after initial treatment with anti-estrogen agents.
The second patent, “Tumor Grading and Cancer Prognosis,” further expands on this theme by identifying gene expression levels correlated with tumor grade. This disclosure offers a molecular index for assessing tumor grade and predicting patient prognosis. It also outlines methods for predicting cancer recurrence and selecting appropriate treatments based on the likelihood of life expectancy, cancer recurrence, and metastasis.
Career Highlights
Throughout his career, Dennis Sgroi has worked in reputable organizations that have enabled him to refine his expertise in medical innovation. Notably, he has been associated with Biotheranostics, Inc. and The General Hospital Corporation. His work in these institutions has been integral in the development of technologies that enhance cancer diagnosis and treatment methodologies.
Collaborations
Sgroi has collaborated with esteemed colleagues, including Mark G. Erlander and Xiao-Jun Ma. These partnerships have fostered an environment of innovation, allowing for the exchange of ideas and advancements in cancer research.
Conclusion
Dennis Sgroi stands out as a pivotal figure in the realm of cancer research and innovation. His patents not only advance scientific understanding but also hold the potential to significantly improve patient outcomes. Through his efforts and collaborations, Sgroi continues to contribute to the evolving field of medical research, bringing hope to patients and advancing cancer treatment strategies.