Location History:
- Brookline, MA (US) (2004)
- Jamaica Plain, MA (US) (1993 - 2011)
Company Filing History:
4 out of 1,370 
2 out of 35 
2 out of 4,442 
Years Active: 1993-2011
Title: Innovations and Contributions of Dennis J. Selkoe
Introduction
Dennis J. Selkoe is a prominent inventor based in Jamaica Plain, MA, known for his significant contributions to the field of neuroscience. He has been instrumental in advancing our understanding of Alzheimer's disease and related conditions through his innovative research and inventions. With a total of seven patents to his name, Selkoe's work has had a profound impact on the development of potential treatments for neurodegenerative diseases.
Latest Patents
Among his latest patents, one notable invention is focused on methods for determining whether a compound alters the amount of at least one αβ (X-41) peptide and the amount of either total αβ or at least one αβ (X-40) peptide produced by a non-human mammal. This invention provides methods of screening compounds for their ability to alter the production of Aβ(x≥41) alone or in combination with Aβ(x≤40). The methods involve administering compounds to cells, specifically measuring the amounts of Aβ(x≤40) and Aβ(x≥41) produced by the cells, and comparing these amounts to that produced by the cells without administration of the compounds. Another significant patent involves the use of novel (hydroxyethyl)ureas as inhibitors of Alzheimer's β-amyloid production. These compounds are effective inhibitors of certain aspartyl proteases, notably secretases involved in the enzymatic cleavage of amyloid precursor protein (APP) to yield amyloid-β peptide. Methods are provided for administering the novel compounds to treat β-amyloid-associated diseases, notably Alzheimer's disease.
Career Highlights
Throughout his career, Selkoe has worked with esteemed institutions such as Brigham and Women's Hospital, Inc. and Athena Neurosciences, Inc. His research has been pivotal in the exploration of amyloid precursor proteins and their role in Alzheimer's disease, contributing to a deeper understanding of the mechanisms underlying neurodegeneration.
Collaborations
Selkoe has collaborated with notable colleagues in the field, including Dale Bernard Schenk and Michael G. Schlossmacher. These collaborations have further enriched his research and have led to significant advancements in the understanding of Alzheimer's disease.
Conclusion
Dennis J. Selkoe's innovative work and patents have made a lasting impact on the field of neuroscience, particularly in the study and treatment of Alzheimer's disease. His contributions continue
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.