Company Filing History:
Years Active: 2016
Title: **Denise Holzle: Innovator in Gene Regulation Technology**
Introduction
Denise Holzle, a pioneering inventor based in Bolingbrook, Illinois, has made significant contributions to the field of biotechnology. With one patent to her name, she is recognized for her innovative work in gene expression systems, which has potential applications in various biotechnological processes.
Latest Patents
Holzle's patent, titled "Regulated gene expression systems and constructs thereof - Compositions and methods for nitrogen sensitive regulation of expression of a transcribable nucleic acid molecule," presents groundbreaking methods for controlling gene expression in response to nitrogen levels. This invention offers a nitrogen-sensitive expression system that includes a transcription factor region with an NtcA binding site and a core promoter region featuring a RuBisCo promoter or its variants. Furthermore, her work provides methods for transforming host cells with this expression system, as well as expression cassettes, transformed host cells, and comprehensive kits for practical applications.
Career Highlights
Denise Holzle is associated with Proterro, Inc., a company that focuses on sustainable and innovative solutions in biotechnology. Her expertise in molecular genetics and gene regulation has positioned her as a valuable asset in advancing the company’s mission to harness the potential of photosynthetic microorganisms for biofuel production and other applications.
Collaborations
Throughout her career, Holzle has collaborated with notable colleagues, including Robert J. Turner and Valerie Sershon. These partnerships have enabled her to blend diverse ideas and expertise, further enhancing the research and development of cutting-edge biotechnological solutions.
Conclusion
Denise Holzle stands out as an influential inventor in the field of gene regulation, with her innovative approach promising to impact various industries. Her dedication to advancing biotechnological research continues to inspire future developments, positioning her as a key figure in the evolution of sustainable biotechnology solutions.
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