Company Filing History:
Years Active: 2000-2002
Title: **The Innovative Contributions of Denise Bernadette Thurber**
Introduction
Denise Bernadette Thurber is an accomplished inventor based in Silver Spring, Maryland, renowned for her significant contributions in the field of genetic research. With a total of four patents to her name, Thurber has made remarkable strides in understanding genetic mutations, particularly concerning the BRCA2 and BRCA1 genes, which play a crucial role in breast and ovarian cancer susceptibility.
Latest Patents
Thurber's latest innovations include the identification of a new mutation in the BRCA2 gene, categorized as susceptibility mutation 6495delGC. This mutation represents a two-base pair deletion of nucleotide 6495 and is transformative in the realm of genetic diagnostics. The patent discloses a process for identifying sequence variations within BRCA2 polynucleotide sequences through allele-specific sequence-based techniques. This method enables efficient detection of mutations in test samples, providing vital information for cancer risk assessment.
In addition, Thurber has been instrumental in advancing research on the BRCA1 gene. Her patented methods relate to isolated coding sequences and their corresponding protein sequences, specifically three coding sequences of the BRCA1 gene, known as BRCA1.sup.(omi1), BRCA1.sup.(omi2), and BRCA1.sup.(omi3). She outlines their frequencies of occurrence and protein translations, which is crucial for diagnosing genetic predispositions to breast or ovarian cancer. Furthermore, Thurber's work encompasses methodologies for gene therapy utilizing BRCA1 coding sequences as well as protein therapy with BRCA.sup.(omi) proteins.
Career Highlights
Throughout her career, Denise Thurber has worked with prominent companies in the biotechnology sector, including Oncormed, Inc. and Gene Logic, Inc. Her experiences in these organizations have significantly influenced the development of her inventions, driving innovation in genetic research and therapeutics.
Collaborations
Thurber has also collaborated with notable peers in the field, including Sheri J. Olson and Tammy Lawrence. These partnerships have fostered an environment of shared knowledge and expertise, further enhancing the impact of her inventions on the scientific community.
Conclusion
Denise Bernadette Thurber's dedication to genetic research demonstrates her exceptional talent and innovative spirit. With her pioneering patents and collaborative efforts, she continues to pave the way for advancements in genetic diagnostics and therapies, fostering hope for countless individuals affected by hereditary cancer predispositions.