Company Filing History:
Years Active: 2001-2009
Title: The Innovations of Denis Portnoi
Introduction
Denis Portnoi is a notable inventor based in Paris, France. He has made significant contributions to the field of biotechnology, particularly in the development of purified antibodies and recombinant screening methods. With a total of 3 patents to his name, Portnoi's work has implications for various applications in medical research and diagnostics.
Latest Patents
Among his latest patents, one notable invention involves purified antibodies that bind to the ERP protein. This patent describes a purified antibody that specifically interacts with a polypeptide comprising SEQ ID NO: 39 or SEQ ID NO: 41. In certain embodiments, the polypeptide has a theoretical molecular weight of approximately 28 kDa, while in others, it has an observed molecular weight of about 36 kDa, as determined by denaturing polyacrylamide gel electrophoresis (SDS-PAGE). The purified antibody may be either a monoclonal or polyclonal antibody. Additionally, the invention includes antibodies that do not specifically bind with the P28 protein. These antibodies have numerous applications, including the identification of Mycobacteria.
Another significant patent focuses on recombinant screening, cloning, and expression vectors that replicate in mycobacteria. This vector is characterized by containing a mycobacteria functional replicon, a selection marker, and a reporter cassette that includes a multiple cloning site (polylinker), a transcription terminator active in mycobacteria, and a coding nucleotide sequence derived from a gene coding for an expression, export, and/or secretion protein marker. This vector is instrumental in the identification and expression of exporter polypeptides, such as the P28 antigen.
Career Highlights
Denis Portnoi is affiliated with the prestigious Institut Pasteur, where he conducts his research and development work. His contributions to the field have been recognized through his patents and the impact of his research on biotechnology.
Collaborations
Portnoi has collaborated with esteemed colleagues, including Brigitte Gicquel and Eng Mong Lim. These collaborations have further enhanced the scope and impact of his research endeavors.
Conclusion
Denis Portnoi's innovative work in the field of biotechnology, particularly in the development of antibodies and recombinant vectors, showcases his significant contributions to medical research. His patents reflect a commitment to advancing scientific knowledge and improving diagnostic methods.