This inventor holds 1 USPTO granted patent. Top assignee: Leland Stanford Junior University. Active years: 2017.
Company Filing History:
Years Active: 2017
Title: Deju Ye: Innovator in Nano-Aggregation Probes
Introduction
Deju Ye is a prominent inventor based in Mountain View, CA (US). He has made significant contributions to the field of biomedical imaging through his innovative work on caspase-triggered nano-aggregation probes. His research focuses on developing advanced tools for detecting apoptotic tumor cells, which can enhance cancer diagnostics and treatment.
Latest Patents
Deju Ye holds 1 patent for his invention titled "Caspase-triggered nano-aggregation probes and methods of use." This patent describes an activatable probe that undergoes intramolecular cyclization and subsequent aggregation in apoptotic tumor cells upon peptidase-initiated activation, particularly through caspase-3. The caspase-sensitive nano-aggregation probes (C-SNAFs) are designed to be biocompatible and possess near-infrared (NIR) spectral properties. They may also serve as imaging agents for PET or MRI, showcasing a mechanism of target-mediated nanostructure self-assembly suitable for in vivo applications. The probes utilize biocompatible condensation chemistry products that include D-cysteine and 2-cyano-6-hydroxyquinoline (CHQ) moieties linked to an amino-luciferin scaffold. Activation occurs through a two-step reaction involving caspase-3/7-mediated cleavage of an aspartate-glutamate-valine-aspartate (L-DEVD) capping peptide and the reduction of the disulfide bond by free intracellular thiols.
Career Highlights
Deju Ye is affiliated with Leland Stanford Junior University, where he continues to advance his research in the field of biomedical engineering. His work has garnered attention for its potential applications in cancer therapy and diagnostics.
Collaborations
Deju has collaborated with notable researchers in his field, including Jianghong Rao and Adam Shuhendler. Their combined expertise contributes to the innovative research environment at Leland Stanford Junior University.
Conclusion
Deju Ye's contributions to the development of caspase-triggered nano-aggregation probes represent a significant advancement in biomedical imaging technology. His work holds promise for improving cancer detection and treatment methodologies.