Deepa Shankar Suvarna

Title: Deepa Shankar Suvarna: Innovator in Peptide Synthesis

Introduction

Deepa Shankar Suvarna is a notable inventor based in Bengaluru, India. She has made significant contributions to the field of peptide synthesis, particularly in the development of liraglutide, a medication used in the treatment of diabetes.

Latest Patents

Deepa holds a patent for the "Synthesis of liraglutide." This invention relates to an efficient solid-phase synthesis process for liraglutide, represented by Formula-I. The method involves sequential coupling of protected amino acids to create the backbone of liraglutide. Upon completion of the linear sequence, the synthesis is extended from the lysine side chain by adding γ-glutamic acid and palmitic acid. The process includes the removal of protective groups, cleavage of the peptide from the solid support, and purification of the crude liraglutide obtained. Additionally, the invention utilizes inorganic salts during coupling and employs a wash with HOBt in DMF solution after the Fmoc-deprotection step to suppress peptide aggregation, ensuring complete reactions and improving process yield.

Career Highlights

Deepa is currently associated with Biocon Limited, a leading biopharmaceutical company. Her work focuses on innovative approaches to peptide synthesis, contributing to advancements in therapeutic solutions.

Collaborations

Some of her notable coworkers include Nitin Patil and Castelino Roopa Jasmine, who collaborate with her on various projects within the company.

Conclusion

Deepa Shankar Suvarna's contributions to peptide synthesis, particularly through her patent on liraglutide, highlight her innovative spirit and dedication to advancing medical science. Her work continues to impact the field positively.