Location History:
- San Mateo, CA (US) (1990 - 1998)
- San Carlos, CA (US) (1992 - 2002)
Company Filing History:
Years Active: 1990-2002
Title: Innovations and Contributions of Deborah L. Higgins in Biotechnology
Introduction
Deborah L. Higgins, residing in San Mateo, CA, is a prolific inventor known for her significant contributions to the field of biotechnology. With a remarkable portfolio of 21 patents, she has developed various innovative solutions aimed at addressing critical health issues. Her work primarily focuses on enzyme inhibition and the development of therapeutic agents, demonstrating her commitment to advancing medical science.
Latest Patents
Among her latest inventions are the multibinding inhibitors of cyclooxygenase-2 (COX-2). This innovation includes compounds that inhibit COX-2, an enzyme that plays a pivotal role in the biosynthesis of prostaglandins, which are vital in the inflammatory response. The multibinding compounds feature between 2 to 10 ligands covalently attached to linkers, which enhance their effectiveness in treating inflammation, pain, and fever.
Another notable patent is for tissue plasminogen activator (t-PA) zymogens and variants. This invention focuses on creating a fibrinolytically active variant of t-PA, engineered to be zymogenic in the presence of plasmin-degraded fibrinogen. This variant is not only significant for its potential application in treating vascular diseases but also offers new pathways for preventing fibrin deposition and complications in mammalian systems.
Career Highlights
Throughout her career, Deborah has made substantial contributions while working at renowned companies such as Genentech, Inc. and Advanced Medicine, Inc. Her dedication and innovative spirit have not only enriched her professional journey but have also made a lasting impact in the biotech sector.
Collaborations
Deborah has collaborated with esteemed professionals, including scientists Stephen P. Anderson and William F. Bennett. These collaborations have facilitated the advancement of her research and the successful application of her inventions in real-world scenarios.
Conclusion
Deborah L. Higgins is a testament to the power of innovation in biotechnology. Through her extensive patent portfolio and collaborative efforts, she continues to push the boundaries of scientific research. Her work promises to enhance the quality of healthcare and improve treatment options for various conditions, reflecting her role as a leading inventor in her field.