Location History:
- Malden, MA (US) (2016 - 2017)
- Boston, MA (US) (2019 - 2023)
Company Filing History:
6 out of 1,210 
2 out of 1,373 
Years Active: 2016-2025
Title: The Innovations of De-Kuan Chang
Introduction
De-Kuan Chang is a prominent inventor based in Boston, MA, known for his significant contributions to the field of biomedical research. He holds a total of six patents, showcasing his innovative approach to developing therapeutic solutions.
Latest Patents
One of his latest patents is focused on humanized CC chemokine receptor 4 (CCR4) antibodies and methods of use thereof. This invention provides humanized monoclonal antibodies, bi-specific antibodies, antibody conjugates, and fusion proteins that bind to the chemokine receptor CCR4. The antibody is derived from CCR4-IgG1 and recognizes the same epitope. It contains either an IgG4 or a stabilized IgG4 to improve binding efficiency and reduce in vivo Fab arm exchange. The binding of these antibodies to CCR4 inhibits ligand-mediated activities and is utilized to treat symptoms of cancer.
Career Highlights
Throughout his career, De-Kuan Chang has worked with esteemed institutions such as Dana-Farber Cancer Institute Inc. and Brigham and Women's Hospital, Inc. His work has significantly impacted cancer research and treatment methodologies.
Collaborations
De-Kuan Chang has collaborated with notable colleagues, including Wayne A. Marasco and Quan Zhu, further enhancing the scope and impact of his research.
Conclusion
De-Kuan Chang's innovative work in developing humanized antibodies represents a significant advancement in cancer treatment. His contributions continue to influence the biomedical field and offer hope for improved therapeutic options.