Company Filing History:
3 out of 313 
2 out of 4 
1 out of 1 Years Active: 2017-2023
Title: Davide Pirolli: Innovator in Cancer and Autoimmune Disease Research
Introduction
Davide Pirolli is a prominent inventor based in Rome, Italy. He has made significant contributions to the fields of cancer treatment and autoimmune disease research. With a total of 3 patents, his work focuses on innovative therapeutic approaches that target specific biological mechanisms.
Latest Patents
One of Davide Pirolli's latest patents involves NEK6 kinase inhibitors useful for the treatment of solid tumors. The mitotic kinases regulating the dynamics of centrosomes and the functions of the mitotic spindle are potential targets for antitumor therapy. In this invention, some molecules with inhibitory activity on NEK6 have been identified. The invention relates to these molecules and the compositions including them for use as inhibitors of NEK6 in a method of treatment of tumors, both in monotherapy and in combinations with other drugs.
Another significant patent focuses on TCR/MHCII-collagen interaction inhibitors useful for the treatment of rheumatoid arthritis. The T cells specific to human collagen type II, one of the possible autoantigens, play a crucial role in the development of rheumatoid arthritis in the context of HLA-DR4. The protein-protein interactions between the T cell receptor (TCR) and the type II collagen linked to the allele MHC of class II HLA-DR4 may represent a target for the development of new drugs against rheumatoid arthritis. Using computational virtual screening techniques, families of pharmacologically active molecules have been identified that interfere with the TCR/collagen II-MHCII interaction. The compounds identified in this patent open up new possibilities in the treatment of rheumatoid arthritis.
Career Highlights
Davide Pirolli has worked with notable institutions such as the Consiglio Nazionale delle Ricerche and Università Cattolica del Sacro Cuore. His research has been instrumental in advancing therapeutic strategies for complex diseases.
Collaborations
Throughout his career, Davide has collaborated with esteemed colleagues, including Maria Cristina De Rosa and Francesco Ria. These partnerships have enriched his research and contributed to the development of innovative solutions in his field.
Conclusion
Davide Pirolli's work exemplifies the impact of innovative research in addressing critical health challenges. His patents reflect a commitment to advancing medical science and improving patient outcomes.