The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 21, 2023

Filed:

Apr. 02, 2019
Applicants:

Consiglio Nazionale Delle Ricerche, Rome, IT;

Molipharma S.r.l., Campobasso, IT;

Inventors:

Maria Cristina De Rosa, Rome, IT;

Davide Pirolli, Rome, IT;

Giovanni Scambia, Campobasso, IT;

Daniela Gallo, Campobasso, IT;

Marco Petrillo, Campobasso, IT;

Marta De Donato, Campobasso, IT;

Benedetta Righino, Campobasso, IT;

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 405/06 (2006.01); C07D 471/04 (2006.01); A61K 33/243 (2019.01); A61K 31/337 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 405/06 (2013.01); C07D 471/04 (2013.01); A61K 31/337 (2013.01); A61K 33/243 (2019.01); A61K 45/06 (2013.01);
Abstract

The mitotic kinases regulating the dynamics of centrosomes and the functions of the mitotic spindle are potential targets for the antitumour therapy. In the present invention some molecules with inhibitory activity on NEK6 have been identified. The present invention relates to such molecules and to the compositions including them for use as inhibitors of NEK6 in a method of treatment of tumours both in monotherapy and in combinations with other drugs.


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